Stuart Little (Stuart Stout) is a main character in House of Animals series. He is Mr. and Mrs. Little's adoptive son, George's little brother, Martha's big brother, Snowbell's friend and "master", Buster's friend and Fievel's Best friend. He was part of his birth family, His birth parents, Reginald Stout and Camille Stout, was killed by Giant Mousetrap and turn them into Mouseburgers. Originally, Stuart Little was getting killed by Giant Mousetrap but, Derpy saves him.

He was voiced by Michael J. Fox in first 3 films and David Kaufman in the TV show and spin offs.